Inheritance of porcine von Willbrand's disease: study of a kindred of over 700 pigs.

نویسندگان

  • D N Fass
  • E J Bowie
  • C A Owen
  • P E Zollman
چکیده

A study of over 700 pigs affected with von Willebrand's disease suggests that the classic disease is transmitted as an autosomal recessive trait. Less clear is the genetic basis of inheritance of variant types of this disease produced by selective mating.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ear necrosis syndrome in weaning pigs associated with PCV2 infection: A case report

Porcine necrotic ear syndrome (PNES) in pigs has been reported as an increasing health problem in many countries with intensive pig farming. The etiology of this disease is complex and the presumed triggering factors can be divided into infectious and non-infectious agents. The present report describes a case of Porcine Circovirus type 2 (PCV2), infection associated with lesions of PNES at the ...

متن کامل

Multiple Sclerosis Diagnosed in a Woman With Von-Willebrand Disease: A Case Report

Background: Von-Willebrand Disease (VWD) is the most common inherited bleeding disorder with an autosomal inheritance pattern. Multiple Sclerosis (MS) is a neurological disease, causing neurodegeneration and demyelination of the central nervous system through autoimmune mechanisms, and is a major cause of non-traumatic disabilities in youths. Some studies have shown the higher plasma activity o...

متن کامل

Genetics of classic von Willebrand's disease. I. Phenotypic variation within families.

In order to determine the phenotypic vanability within families transmitting classic von Willebrand’s disease (vWd). a single cross-sectional examination was made of two large seven-generation vWd kindred living in the Carolinas. A total of 181 subjects were examined at least once. Fifty-eight were classified as “affected.” 24 in the smaller kindred of 41 8 persons and 34 (2 of whom were homozy...

متن کامل

Platelet storage pool deficiency in pigs.

We report a new bleeding disease--storage pool deficiency (SPD) of platelets--in pigs from the Mayo swine colony of homozygous von Willebrand's disease (vWD) and of heterozygous carriers of vWD. Levels of factor VIII, von Willebrand factor antigen (vWF:Ag), and ristocetin cofactor (RCof) were similar in the vWD carriers and SPD pigs. The latter pigs, however, had bleeding times of 15 minutes or...

متن کامل

Effect of vitamin C on tracheal responsiveness and pulmonary inflammation in chronic obstructive pulmonary disease model of guinea pig

Introduction: In the present study, the prophylactic effect of vitamin C, as a potent anti-oxidant, on tracheal responsiveness to methacholine and ovalbumin, bronchoalveolar lavage fluid white blood cell (WBC) count and differential count, and also lung pathology in chronic obstructive pulmonary disease (COPD) -guinea pigs (cigarette exposed guinea pigs) were examined. In addition, the relax...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Blood

دوره 53 4  شماره 

صفحات  -

تاریخ انتشار 1979